Our Science

Proteins are typically studied as isolated entities, but in nature function in protein communities – interconnected networks of dynamic protein interactions. Medical research has been limited by an incomplete understanding of how these networks impact diseases.

Interline is developing a precision medicine platform to map and modulate protein communities, leveraging recent advancements in genomics, proteomics, structural biology and computational chemistry.

Proteins are the proximal translation of genetic information into multidimensional, broadly druggable chemical space.

Advances in multiple disciplines are aligning to expose previously hidden dimensions of protein communities in their native context. Interline is using this information to develop new medicines for genetically validated signaling pathways.

The reactions of life depend on dynamic protein molecular machines. Modulating the manner in which these machines interact – the key inputs and outputs of protein function – offers tremendous potential for developing new therapies.

Brenda Schulman

Founding Scientific Advisor

Scientific Focus

Interline has developed a drug discovery platform focused on three essential areas:


Our genomics pipeline prioritizes genetic variants that drive disease by altering protein communities.


We integrate experimental proteomics and machine learning techniques to identify the detailed molecular mechanisms through which genetic variants change protein community dynamics.


Advanced biophysics, structural biology and computational capabilities enable us to discover and characterize drugs that reshape these communities.

Interline Interstellar

The Interline Interstellar platform integrates best-in-class mass spectrometry and computational proteomics to characterize functionally relevant protein interactions