Kyle Simonetta

Kyle is a biochemist and structural biologist, with a passion for identifying and progressing small molecules that modulate protein-protein interactions, especially those that form cooperative ternary complexes. At Interline, Kyle leads a team of talented scientists in the biophysical and structural characterization of protein-protein interactions and the discovery of small molecule effectors of those interactions. Kyle received a Ph.D. from UC Berkeley in the laboratory of John Kuriyan, studying the structural mechanisms of DNA replication and subsequently conducted postdoctoral research in the ubiquitin field in Micha Rape’s lab. Most recently, he worked in the field of targeted degradation as the first employee at Nurix Therapeutics, developing molecular glues and heterobifunctional molecules that recruit targets to ubiquitin ligases for ubiquitylation and degradation. He is a 17 year Bay Area transplant from New England (Go Sox!) and enjoys hiking and going on trips with his family.